Scientist - Downstream
Company: Yoh, A Day & Zimmermann Company
Posted on: April 9, 2021
Yoh is a seeking a Scientist, Downstream to support an
Emeryville Area based company. You will have the opportunity to
work within the Manufacturing, Sciences and Technology (MS&T)
team to develop robust recombinant protein downstream processes in
support of developing and optimizing production processes including
process parameter optimization, process characterization,
scale-up/tech transfer for large scale product production and
support successful implementation of production processes at
Title: Scientist, Downstream
Location: Emeryville, CA
Type: 1 year contract
Pay: Competitive, depends on experience
Responsibilities include but are not limited to:
Independently prepares and edits procedures or technical reports of
a complex nature, including data interpretation, suitable for
Direct interaction and effective collaboration with project team
members, including presenting data at project team meetings;
critical review of data; and active involvement in solving
technical challenges that arise during development.
The individual will be accountable for scientific data review
including data integrity verification, statistical analysis and
technical report writing.
Maintains laboratory facilities and equipment in accordance with
company policies (inclusive of safety) and industrial best
Lead/assist in the efforts for developing and optimizing downstream
processes including process parameter optimization, process
characterization and scale-up/tech transfer for large scale product
Education and Experience Requirements:
Educational degrees must be relevant to position (e.g., Biology,
Biochemistry, Chemistry, or Toxicology): PhD +7 years, MS +10 years
or BS +12 years' experience in product development, manufacturing
science and technology, process engineering within the
pharmaceutical industry required. Title to be adjusted based on
Key Skills, Abilities, and Competencies:
Proficient with the use of MS Office software (MS Excel, MS Word,
MS Powerpoint) and application software including Unicorn, JMP,
Minitab, Design Expert, etc.
Complexity and Problem Solving:
Has considerable knowledge and technical expertise in protein
purification of recombinant proteins and monoclonal antibodies.
Hands-on experience in modern protein purification techniques
(chromatography, affinity, ion-exchange, hydrophobic, mixed mode,
experience working with AKTA, Unicorn, clarification/filtration,
and ultrafiltration/diafiltration) is required.
Execute protocols ranging from resin screening, chromatography,
filter sizing and TFF optimization.
Working knowledge of AKTA Avant, Pilot, and/or Ready systems and
associated software, AKTA Unicorn and Assist software.
Working knowledge and ability to program Unicorn and Assist Plate
Reader software or an equivalent.
Knowledge of process scale-up and scale-down methodologies,
including process characterization and design of experiments
Experience in process technology transfer within and between
organizations, manufacturing support and troubleshooting
Design and write up studies to characterize Downstream process
parameters with high risks identified in the Lifecycle Stage 1 risk
assessments to define their criticality and to define Proven
Acceptable Ranges (PAR) for Critical Process Parameters (CPPs)
Understanding of basic statistical data analysis and a willingness
to explore advanced statistical modelling tools.
Working knowledge and experience working in cGMP environments
(understanding of equipment, technology, and quality systems
Skilled in application of standardized root cause analysis,
investigation tools and methodologies.
Strong organizational skills in prioritizing personal tasks to meet
deadlines and collaborate proactively with achieving goals.
Demonstrated ability to develop new techniques, solve complex
problems, author technical protocols and reports; and evaluate and
implement new instrumentation or process techniques.
Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer.
All qualified applicants will receive consideration for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, national origin, disability, or status as a
protected veteran. Visit
https://www.yoh.com/applicants-with-disabilities to contact us if
you are an individual with a disability and require accommodation
in the application process.PandoLogic.Category: Science, Keywords:
Keywords: Yoh, A Day & Zimmermann Company, Oakland , Scientist - Downstream, Other , Oakland, California
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