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Research Associate II, Protein Synthesis, R&D

Company: Resilience
Location: Oakland
Posted on: November 22, 2022

Job Description:

In this position, you will help expand the applications of cell-free technology in the biopharmaceutical industry by supporting and executing research and development projects. The work will involve cell-free and cellular protein synthesis optimization, protein purification, and protein characterization using SDS-PAGE, absorbance-based methods, and immunoassays. You'll also work with our platform development team to improve our platform to make a wider variety of proteins and scale-up the cell-free protein synthesis process from the bench scale to GMP clinical batches.Responsibilities

  • Design and execute experiments to screen, characterize, and produce preparative amounts of protein therapeutic candidates.
  • Perform and optimize cell-free protein expression of various therapeutic proteins.
  • Prepare and validate materials for cell-free protein expression for use at the bench and pilot scale.
  • Purify proteins at scales from magnetic beads to AKTA systems.
  • Characterize proteins using chromatography, absorbance-based methods, SDS-PAGE, and immunoassays.
  • Design DNA using synthetic biology-based methods.
  • Perform experiments using PCR, protein and DNA electrophoresis, Western blotting, expression, cell culture (bacterial).
  • Interpret and present experimental data to colleagues and company leadership.
  • Prepare reagents for testing and process samples via automated systems in accordance with the laboratory's standard operating procedures (SOPs).
  • Help improve and build upon our cell-free synthesis, purification, and characterization platform to deliver new classes of proteins, expand throughput, and increase speed.Qualifications
    • Required Direct experience working with molecular cloning, protein expression, purification, and characterization (preferably of protein therapeutics).
    • Required BS (+2 years experience) or MS (with highly-related thesis experience), in Bioengineering, Biochemistry, Microbiology Synthetic Biology, Biological Engineering, Biomedical Engineering, Biotechnology, Chemical Engineering, or related fields.
    • Demonstrated ability to interpret, compile, and present experimental data.
    • Ability to work in a fast-paced, team-based small company environment with a drive to creatively solve problems around how to speed up protein therapeutic development and experimental workflows.
    • Availability to work full-time hours at our Oakland, CA location.
    • High intrinsic motivation and a desire to learn new techniques.
    • Direct experience with in vitro transcription-translation or cell-free protein synthesis methods.
    • Preferred Direct experience with automation and high-throughput workflows.
    • Preferred Experience with cell-free protein synthesis techniques.Our work environment is focused on treating everyone on our team with respect, fostering a collaborative environment, taking ownership of our work, learning new skills, and having fun.

Keywords: Resilience, Oakland , Research Associate II, Protein Synthesis, R&D, Other , Oakland, California

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